Dissertation on niosomes
Bilosomes as a Drug Delivery System
Uptake and degradation of niosomes (non-ionic surfactant vesicles) in a living, unicellular, eukaryotic micro-organism was also investigated. It was found that the rate of release of contents depended on the composition of the vesicles and was a function of enzymatic degradation within these organisms rather than an intracellular pH effect of the digestive organelle. 1/04/ · Niosomes are the bi-layered structure of non-ionic surface-active agents. These thermodynamically stable bilayered structures are formed only when surfactants and cholesterol are mixed in a proper proportion, and the temperature is above the gel liquid transition temperature [7,21,22].This bi-layered structure contains a hollow space in the center. NIOSOMES Dissertation submitted to THE TAMILNADU Dr. M.G.R. MEDICAL UNIVERSITY, CHENNAI in partial fulfillment of the requirement for the award of degree of MASTER OF PHARMACY IN PHARMACEUTICS March - DEPARTMENT OF PHARMACEUTICS MADURAI MEDICAL COLLEGE MADURAI CONTENTS CHAPTER NO.
UBC Theses and Dissertations
Niosomes have also been widely studied as drug carriers for controlled and targeted delivery 3, 4. Preliminary studies indicate that niosomes behave in vivo like liposomes, prolonging the circulation of entrapped drug to alter its organ distribution and metabolic stability, or prolonging contact time of drug with the applied tissues in topical application Design and Characterisation of Niosomes for Ocular Delivery of Naltrexone Hydrochloride. Hamdy Abdelkader Mohamed Abdelkader. A thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy, School of Pharmacy, The University of Auckland. 1/04/ · Niosomes are the bi-layered structure of non-ionic surface-active agents. These thermodynamically stable bilayered structures are formed only when surfactants and cholesterol are mixed in a proper proportion, and the temperature is above the gel liquid transition temperature [7,21,22].This bi-layered structure contains a hollow space in the center.
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List of Dissertation Abstract In a dilute region, small niosomes of about 80 nm and bicelle of about 20nm were formulated by ultrasonication, cholesterol addition in this surfactant lamellar phase induced the phase transition to the liquid ordered phase. Niosomes were prepared by using span80 and cholesterol by different methods. Dicetyl phosphate and stearylamine were used to obtain negatively and positively charged vesicles respectively. Prepared niosomes were evaluated for entrapment efficiency, particle size distribution, stability studies, and corneal permeation studies along with in vivo intra ocular pressure lowering capacity in adult. NIOSOMES Dissertation submitted to THE TAMILNADU Dr. M.G.R. MEDICAL UNIVERSITY, CHENNAI in partial fulfillment of the requirement for the award of degree of MASTER OF PHARMACY IN PHARMACEUTICS March - DEPARTMENT OF PHARMACEUTICS MADURAI MEDICAL COLLEGE MADURAI CONTENTS CHAPTER NO.
Supplementary files
1/04/ · Niosomes are the bi-layered structure of non-ionic surface-active agents. These thermodynamically stable bilayered structures are formed only when surfactants and cholesterol are mixed in a proper proportion, and the temperature is above the gel liquid transition temperature [7,21,22].This bi-layered structure contains a hollow space in the center. Uptake and degradation of niosomes (non-ionic surfactant vesicles) in a living, unicellular, eukaryotic micro-organism was also investigated. It was found that the rate of release of contents depended on the composition of the vesicles and was a function of enzymatic degradation within these organisms rather than an intracellular pH effect of the digestive organelle. 1/07/ · 1. Introduction. Niosomes (non-ionic surfactant vesicles) are microscopic vesicles consisting of an aqueous core enclosed by a membrane of non-ionic surfactants that form closed bilayer structures based on their amphiphilic nature (Uchegbu and Vyas, ).The lipophilic groups are located in the interior of membrane while the hydrophilic groups are exposed to the aqueous medium.
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The aim of this thesis was to prepare and characterize bilosomes and assess their potential as an oral drug delivery system for the hydrophilic peptidomimetic drug cefotaxime (CTX). BS used to make bilosomes included sodium cholate (NaC), deoxycholate (NaDC), taurocholate (NaTC) and monoketocholate (NaMKC). PEGylation of Niosomes John A. Elliott University of South Florida Follow this and additional works at: This Dissertation is brought to you for free and open access by the Graduate School at Scholar Commons. It has been accepted for inclusion in Graduate Theses and Dissertations by an authorized administrator of Scholar Commons. Niosomes are the bilayer-structured nanoparticles shaped by self-association of nonionic surfactants and cholesterol in the aqueous phase. Doctoral dissertation, Google Scholar. Tabata, Y, Ikada, Y. Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage.